BIPs 2010
Bridge 2 Industry Projects Approved in 2010:
Title: Development and Application of CHIP-LC-MS Technology for Systems Biology Research
Applicant: Dr. Bernd Wollscheid (ETHZ)
Industry Partner: Dr. John Fjeldsted, Agilent Technologies
Scientific Fields/Keywords:
- Strategic Partnership
- CHIP-LC-MS technology development
- Systems Biology
- Proteomics
Title: Systems-level Analysis of Ras-driven Tumor Metabolism Across Growth Conditions – 2D Plastic to 3D to Xenografts to Tumors
Applicant: Prof. Uwe Sauer (ETHZ)
Industry Partner: Dr. Edward Drigger, Agios Pharmaceuticals
Scientific Fields/Keywords:
- Oncology
- Metabolomics
- In vitro/in vivo cancer models
- Ras tumors metabotyping
Title: Development of a High Precision Cellular Nanoinjection Technology: a Demonstration with HeLa Cells
Applicants: Dr. Tomaso Zambelli (ETHZ), Prof. Julia Vorholt (ETHZ)
Industry Partner: Dr. Michael Gabi, Cytosurge LLC
Scientific Fields/Keywords:
- Nanobiotechnology
- Single-cell injection
- Metabolites
- Microengineering
- Nanofluidics
Title: Simulation and Visualization of Crowding and Combinatorial Signaling
Applicant: Prof. Heinz Koeppl (ETHZ)
Industry Partner: Dr. Pablo de Heras Ciechomski, ScienceVisuals Sarl
Scientific Fields/Keywords:
- Stochastic processes
- Computational systems biology
- Spatial simulation
- Computer graphics
- Virtual reality
Title: High Resolution Mass Spectrometry for Simultaneous Qualitative and Quantitative Analysis of Xenobiotic and Endogenous Metabolites
Applicant: Prof. Gérard Hopfgartner (UniGE)
Industry Partner: Dr. Ron Bonner, AB Sciex
Scientific Fields/Keywords:
- Analytical Chemistry
- High resolution mass spectrometry
- MS acquisition workflow
- Metabolism
- Metabolomics
- MS data mining
Title: Identification of Synaptic Core Pathways as Targets for Autism Treatment
Applicant: Prof. Peter Scheiffele (UniBS)
Industry Partner: Dr. Will Spooren, Hoffmann - La Roche
Scientific Fields/Keywords:
- Neuroscience
- Autism
- Synapse
- Mouse models
- Pharmacological treatment
- Neural development
Title: High Content Screening by Digital Holographic Imaging
Applicants: Dr. Gerardo Turcatti (EPFL), Dr. Pierre Marquet (EPFL)
Industry Partner: Dr. Yves Emery, Lyncée tec SA
Scientific Fields/Keywords:
- Digital Holographic Microscopy (DHM)
- High Content Screening (HCS)
- Toxicity assays
- Cell Viability
- Chemical interference siRNA
- Gene knockdown
Title: Development of Kinetic Models of RNA-dependent Silencing
Applicant: Prof. Mihaela Zavolan (UniBS)
Industry Partner: Dr. Nicole Meisner, Novartis Institutes for Biomedical Research
Scientific Fields/Keywords:
- Computational modeling
- RNAi
- miRNA
- siRNA
- Gene silencing
- Kinetic model
Title: Gene Co-regulation Network Inference and Visualization Based on Novel Bicluster Maps
Applicant: Prof. Wilhelm Gruissem (ETHZ)
Industry Partner: Dr. Stefan Bleuler, Nebion AG
Scientific Fields/Keywords:
- Bioinformatics
- Biclustering
- Gene expression regulation networks
- Transcriptome analysis