BIPs 2011
Bridge 2 Industry Projects Approved in 2011:
Title: Structure-phenotype Relationship of Drugs: the Microtubule Cytoskeleton as a Model System
Applicants: Dr. Michel Steinmetz (PSI), Dr. Andrea Prota (PSI)
Industry Partner: Dr. Heidi Lane, Basilea Pharmaceutica
Scientific Fields/Keywords:
- Structural Biology
- Biochemistry
- Cell Biology
- Microtubule
- X-ray crystallography
Title: SpidX: An Integrated Platform for Spider Venomics
Applicants: Dr. Frédérique Lisacek (SIB), Prof. Wolfgang Nentwig (UniBE)
Industry Partners: Dr. Reto Stöcklin, Atheris Laboratories, and Dr. Roman Mylonas, GeneBio SA
Scientific Fields/Keywords:
- Spider toxins / Antivenoms
- Bioinformatics / EST
- Drug Discovery
- Insecticides
- Mass Spectrometry / Proteomics
- Transcriptomics
Title: A Systems Biology Approach to Identify Instructive 3D Stem Cell Microenvironments
Applicant: Dr. Matthias Lutolf (EPFL)
Industry Partner: Dr. Simone Rizzi, QGel SA
Scientific Fields/Keywords:
- Embryonic stem cells
- 3D artificial extracellular matrix
- Cell-based assays
- High-throughput screening
- Tissue engineering
- Tissue/disease modeling
Title: System-wide Identification of Novel MALT1 Substrates
Applicant: Dr. Ulrich Auf dem Keller (ETHZ)
Industry Partner: Dr. Samu Melkko, Novartis
Scientific Fields/Keywords:
- Biochemistry
- Proteomics
- Protease
- Substrate
- Lymphoma
Title: Real-time Analysis of the Steady State Levels of Riboflavin and Pathway Intermediates in Cell Free Extracts Upon Perturbation of the Rib Enzyme Configuration - a Basis for a Rational Design of a Multienzyme Network
Applicant: Prof. Dr. Sven Panke (ETHZ)
Industry Partner: Dr. Hans-Peter Hohmann, DSM
Scientific Fields/Keywords:
- Systems Biotechnology
- Real-time mass spectrometry
- Vitamin production
- Pathway
- Optimization